Two dozen leaders of the world’s most distinguished universities gathered in Glion-above-Montreux, Switzerland, to compare how their institutions best determined their priorities and plans in the face of the many challenges and constraints they face. The increasing globalization of higher education was apparent in many common issues such as financial constraints, completion for outstanding faculty and students, rapidly evolving technologies, and the economic and workforce needs of their regions. Yet the unique characteristics of these universities and their environments they served led to quite different strategies for balancing responsibilities, challenges, and constraints. This volume contains both the papers presented by the participants in the Xth Glion Colloquium as well as summaries of their discussions. It provides a fascinating perspective of the strategic planning of leading universities from around the world.