Over the past decade, the Glion Colloquium has established itself as an influential resource in addressing the challenges, roles, and responsibilities of the world's research universities. In this book, university leaders from around the world consider how their institutions should respond to the challenge of profound economic, technological, social, and political change. It was developed from topics discussed at the IX Glion Colloquium in 2012. The book discusses not only how research universities are adapting to major changes, but also how they can develop new curricula, student experiences, research paradigms, social engagement, and international alliances to better address the many challenges these changes create.