This book presents original results on the leading edge of cancer research. Topics discussed include the emerging roles of the Sirtuin family in cancer; coping with pain in children with leukaemia; chemotherapy induced peripheral neurotoxicity; historical evolution of conservative surgery of breast cancer; peripheral neuropathies especially in cancer patients; the important pitfalls in the diagnosis of cancer in the oral cavity using 18F-FDG-PET-CT; anthracyclines and cardiotoxicity; current therapies and latest developments in cancer treatment; and the genetic and epigenetic changes in thyroid cancer.