This issue of Clinics in Geriatric Medicine, Guest Edited by James Watson, MD, will feature such article topics as: Frailty and Late Life Decline; The Epidemiology of Frailty and Late Life Vulnerability; The Physiology of Frailty; Frailty and Muscle Mass Decline; Frailty and Anemia; Immune System Alterations in Frailty; CMV/ Viral Infections and Frailty; Frailty and Chronic Disease; Aging Biology and Frailty; Genetic Precursors to Frailty; Frailty Interventions: Exercise; Nutritional Interventions: Vitamin D.