On 27 January 1945 Otto Frank was liberated from Auschwitz by Russian soldiers. At that point not only his journey home started, but also his long quest to find out what had happened to his wife Edith, his daughters Margot and Anne and the four other people with whom he had been in hiding in the Annex at 263 Prinsengracht in Amsterdam: Herman and Auguste van Pels, their son Peter and dentist Fritz Pfeffer. In the months after his liberation Otto Frank would discover that he is the only survivor out of these eight people.

After the Annex continues the journey that Otto began. It is the ultimate attempt, based on thorough research in archives and available eye witness accounts, to reconstruct as precisely as possible what happened to the eight people in hiding after their arrest.