In the dynamic landscape of bioinformatics and blockchain technology, a profound challenge has emerged, begging for an ingenious solution. The exchange and analysis of biological data faces an enduring dilemma: the struggle for data integrity and ownership. The existing conventional methods, while proficient in some domains, fall short when it comes to ensuring the seamless transfer of intricate genomic data. This impasse, though daunting, is now met with a groundbreaking solution that fuses the powers of blockchain innovation and optimization algorithms. Bio-Inspired Optimization Techniques in Blockchain System, is a meticulously curated book designed to confront the heart of an issue which has stymied researchers and academicians alike, which is data integrity and ownership in the bioinformatics and blockchain technology fields. Despite the intricacies of genomic data, researchers have found an unexpected solution in blockchain technology. However, the implementation of this solution is hindered by the colossal scale of data, sluggish transaction speeds, and querying constraints. These obstacles, though formidable, are addressed with precision through the lens of optimization algorithms. This seminal work doesn't just offer a solution; it ushers in a paradigm shift. The editors' expertise in bioinformatics, blockchain, machine learning, and optimization techniques culminates in a comprehensive guide that dissects the fusion of blockchain's architecture and biological data intricacies. The book provides a blueprint for harnessing blockchain's potential to store genomic variants and reference-aligned reads through innovative database indexing methods. By elegantly combining theory with practice, Bio-Inspired Optimization Techniques in Blockchain System empowers technology developers, data scientists, academics, and researchers to surmount the technological hurdles that have long impeded progress. It's a transformative voyage into a future where data integrity and analysis find a harmonious convergence, redefining the boundaries of bioinformatics and beyond.