This interesting book is a compilation of the lectures and discussions held during a four-day event — Grand Challenges for Science in the 21st Century — organized by Para Limes at the Nanyang Technological University in Singapore.The elite group of speakers included Nobel laureate Sydney Brenner who called on all scientists to adopt a truth-seeking approach and not be afraid of challenging assumptions. The other panellists were Martin Rees, Astronomer Royal and past President of the Royal Society, the much-cited Terrence Sejnowski from the renowned Salk Institute for Biological Studies, the well-known keynote speaker in economics and complexity sciences Brian Arthur, the former President of the European Research Council Helga Nowotny and the Director of the Parmenides Center for the Conceptual Foundations of Science Eors Szathmary.The lively sessions were moderated by the Danish writer Tor Norretranders. The panel tackled topics from evolution and the origin of the universe to modern technologies and artificial intelligence. The challenges presented during the event are bound to get the reader thinking about what may lie ahead in our future.Published in collaboration with Institute Para Limes.