This innovative book clarifies the distinction between philosophy of medicine and medical philosophy, expanding the focus from the 'knowing that' of the first to the 'knowing how' of the latter. The idea of patient and provider self-discovery becomes the method and strategy at the basis of therapeutic treatment. It develops the concept of 'Central Medicine', aimed at overcoming the dichotomies of Western-Eastern medicine and Traditional-Integrative approaches. Evidence-based and patient-centered medicine are analyzed in the context of the debate on placebo and non-specific effects alongside clinical research on the patient-doctor relationship, and the interactive nature of human relationships in general, including factors such as environment, personal beliefs, and perspectives on life's meaning and purpose. Tomasi's research incorporates neuroscience, psychology, philosophy, and medicine in a clear, readable, and detailed way, satisfying the needs of professionals, students, and anyone who enjoys the exploration of the complexity of human mind, brain, and heart.