Cultural Agents Reloaded: The Legacy of Antanas Mockus systematically reflects on the practices and legacy of one exceptional cultural agent, Antanas Mockus, twice Mayor of Bogotá, Colombia. His accomplishments bear witness to the potential of creative, symbolic practices as a trigger for social change. His failures, in turn, demonstrate what happens when cultural agency and epistemic legitimacy take divergent paths. Mockus’s example motivates us to further revise and sharpen our understanding of what cultural agency is in the present day by bringing into focus some of the most formidable challenges that public humanities face when they travel South and struggle to become genuinely global.