This book constitutes the proceedings of the 14th International Conference on Social, Cultural, and Behavioral Modeling, SBP-BRiMS 2021, which was held online during July 6–9, 2021.The 32 full papers presented in this volume were carefully reviewed and selected from 56 submissions. The papers were organized in topical sections as follows: COVID-related focus; methodologies; social cybersecurity and social networks; and human and agent modeling. They represent a wide number of disciplines including computer science, psychology, sociology, communication science, public health, bioinformatics, political science, and organizational science. Numerous types of computational methods are used including, but not limited to, machine learning, language technology, social network analysis and visualization, agent-based simulation, and statistics.