Fully updated for the second edition, this book introduces the growing and dynamic field of particle astrophysics. It provides an overview of high-energy nuclei, photons and neutrinos, including their origins, their propagation in the cosmos, their detection on Earth and their relation to each other. Coverage is expanded to include new content on high energy physics, the propagation of protons and nuclei in cosmic background radiation, neutrino astronomy, high-energy and ultra-high-energy cosmic rays, sources and acceleration mechanisms, and atmospheric muons and neutrinos. Readers are able to master the fundamentals of particle astrophysics within the context of the most recent developments in the field. This book will benefit graduate students and established researchers alike, equipping them with the knowledge and tools needed to design and interpret their own experiments and, ultimately, to address a number of questions concerning the nature and origins of cosmic particles that have arisen in recent research.