The aim of this volume of scientific essays is twofold. On the one hand, by remembering the scientific figure of Eduardo R. Caianiello, it aims at focusing on his outstanding contributions – from theoretical physics to cybernetics – which after so many years still represent occasion of innovative paths to be fruitfully followed. It must be stressed the contribution that his interdisciplinary methodology can still be of great help in affording and solving present day complex problems. On the other hand, it aims at pinpointing with the help of the scientists contributing to the volume – some crucial problems in present day research in the fields of interest of Eduardo Caianiello and which are still among the main lines of investigation of some of the Institutes founded by Eduardo (Istituto di Cibernetica del CNR, IIAS, etc).