This book investigates the state of civilisation in the 21st century, which is characterised by the transformation of Western Civilisation into Global Civilisation and the resulting Great Recession, triggered by the financial crisis in the United States in 2008. Since the state of former Western Civilisation is steadily worsening, the question is rising whether civilisation is sustainable at all. To answer this question, 20 authors, members of the International Society for the Comparative Study of Civilisations (from several countries and continents) investigate the aspect of human spirituality, and whether its actual level of development is able to steer the sustainable development of civilisation? The authors investigate the complexity of the current state of world civilisation and the Planet, concluding that western societies entered the Second Great Crisis of Civilisation, and reminding that the First Great Crisis took place after the fall of Rome I in 476 CE, and lasted till the Italian Renaissance, which means almost 1000 years. This book offers spirituality 2.0 as a possible "tool" for people to behave wisely in order to sustain our civilisation. This new spirituality 2.0 contains a set of complementary best values of current eight civilisations, which should lead to tolerant (less-conflict driven) human behaviour and wise decision-making. The book finally defines Wise Civilisation and paths of its implementation, under the condition that people will be not only knowledgeable, but wise and inspired mainly by right spirituality.