This book presents a selection of manuscripts submitted to the 2nd International Conference on Geospatial Information Sciences 2021, a virtual conference held on November 3-5, 2021. These papers were selected by the Scientific Program Committee of the Conference after a rigorous peer-review process. They represent the vast scope of the interdisciplinary research areas that characterize the Geospatial Information Sciences that is done in the discipline. It especially represents a fabulous opportunity to showcase research carried out by young Mexican researchers and showcase it to the rest of the world and enhance the growth of the sciences in the country while, at the same time, enforces them to level up with other research at the international level.