This book constitutes the thoroughly refereed post-conference proceedings of the 13th International Conference on Mobile Computing, Applications, and Services, MobiCASE 2022, held in Messina, Italy, in November 17-18, 2022. The 9 full papers were carefully reviewed and selected from 25 submissions. The papers are organized in topical tracks: mobile computing; machine learning/deep learning; dependable systems; and emerging applications.