Capsaicin, the Pungent Principle in Hot Pepper: From Basic Pharmacology to Therapeutic Applications is a comprehensive reference on the biology and pharmacological characteristics of this key active principle. Capsaicin is known for having diverse physiological and pathophysiological actions, ranging from appetite control through blood pressure regulation to pain relief and oncology. This book's content is presented in three sections. The first covers the historic development of research in the area, from the discovery and isolation, to the identification of its receptor, and antagonists. The second part focuses on the biological effects and pharmacology, including nociception and pain, salivary secretion, body temperature regulation, and blood pressure regulation. The final part provides a current overview of the clinical applications and discusses possible future developments including desensitization, pain relief, injections, effects on the tumor microenvironment, appetite control, and longevity. Capsaicin, the Pungent Principle in Hot Pepper: From Basic Pharmacology to Therapeutic Applications provides pharmacology researchers both in the lab and clinical settings with the needed information to apply and develop new treatments based on capsaicin's unique characteristics. Clinicians in pain management and cancer will benefit from the biology foundation provided by the author.

• Provides historical background on capscaicin research, from the domestication all the way to the 2021 Nobel Prize winning research
• Explores the scientific basis of longevity use of capsaicin
• Covers the state-of-art on the biology, pharmacology, and potential clinical applications of capsaicin