Two years after to tragic loss of his wife and child, Jesup Beal remains consumed by grief and guilt. Time has not healed his wounds, only deepened them. Longing for the release of death, Jesup begins walking the dark streets of a city caught in the grip of a prolific serial killer; tempting fate to do what he cannot. When finally confronted by death, it is not the peaceful release he had sought. Instead, he is bitten by a vampire and cursed to an immortality locked in his grief. With the vampire that infected him as his only ally, Jesup's only hope for salvation lies with reaching the Brazen Serpent, an ancient religious relic believed to heal the vampire curse.