This open access book focuses on the impact of the COVID-19 pandemic on well-being, happiness and quality of life, taking into account the mediating effects of social inequalities. The volume brings together and into dialogue the different experiences and perspectives of countries and researchers from the Global North and South. Expert scholars from across the world have analyzed empirical data to reveal how the restrictions associated with the pandemic interrupted lives and livelihoods, and how different socio-economic groups and classes have been differently affected by the crisis. The chapters coalesce around four themes: the impact of COVID-19 on subjective well-being, life satisfaction and happiness in a comparative and longitudinal perspective; the impact of COVID-19 on employment and workers’ well-being; sociability, civic participation and solidarity during COVID-19; and the impact of COVID-19 on children’s and youths’ well-being. Engaging with contemporary theoretical debates on well-being, happiness and quality of life, this volume is of interest to scholars working on well-being, happiness and quality of life, global and cross-national studies, the social impact of COVID-19, and on social and economic change.