Even though some school-based tobacco use prevention programs have proven successful, nearly all first use of tobacco occurs before high school graduation. In this volume the authors offer a health researcher′s perspective on the history, status, and requirements of school-based tobacco use prevention and cessation research. They outline how to develop a research program and give practical guidelines on how to implement it. Following a brief overview of school-based prevention and cessation programs, they describe the development and implementation of Project Towards No Tobacco Use (TNT), and address major theoretical and methodological issues. The specific issues they address include developing and selecting good programs; developing the curriculum; examining the social influences of etiology; and selecting, assigning, and teaching subjects. Researchers and practitioners in public health, especially those involved in adolescent tobacco programs and health promotion will find this volume particularly interesting.