This volume summarizes exciting developments in the therapy of liver disease and not just those using cellular methods New therapies discussed here will include other genetic and gene editing therapies such as CRISPR/Cas9 technology, which is one of the most important new developments in molecular biology. Other topics will include novel stem cell sources of therapeutic cells, bioartificial devices and bioengineered livers for transplantation, and other functioning long-term in preclinical models. New treatments for fibrosis / cirrhosis, which might reverse cirrhosis or reprogram fibroblasts restoring liver function, are reviewed.