Everyone is talking about digitization and artificial intelligence today. Many think of self-driving cars and self-thinking robots, although the future here already affects the present. However, digital processes and communications have long since determined everyday work in the health professions. What is routine, what makes everyday life easier, where are fears and justified skepticism? This issue of Leidfaden spans the spectrum from the hospital information system and the nursing robot to algorithmic decision-making in medicine and nursing to pastoral care and therapy in social networks. And as far as everyone is concerned: what happens to our digital estate? All of the articles in this issue do not come from intelligent writing robots, but from experts from the flesh and blood.