This book offers an examination of Africa’s scientific landscape based on extensive empirical data encompassing fifty-four African countries. It traces the evolution of science on the continent, highlighting research areas, global partnerships, funding sources, research capacity, and the impact of science policies. Acknowledging that Africa relies heavily on external sources, particularly from the Global North, for scientific research, the book identifies and addresses obstacles hindering self-reliance and underscores the urgent need for revitalized partnerships and cooperation to bolster Africa's scientific autonomy. It offers valuable recommendations to promote self-reliance, making it an indispensable resource for scholars, policymakers, and practitioners.