Responding to the explosion of research on the pathophysiology and management of bipolar disorder, this completely revised Second Edition spans basic mechanisms, neuroimaging, viral etiology, neurofactors, current treatment implications, and modern theories of the neurobiology of bipolar disorder to stand as the most authoritative reference on this debilitating condition. Written and edited by internationally lauded experts in the field, this source covers an expansive array of topics including genetic and causal factors, neuroendocrinology, neurotransmitters and signal transduction pathways, neuroimaging and neurorecognition, and prospects for new treatment development.