The emergence of start-up companies and new forms of entrepreneurship has become a significant challenge for entrepreneurs and decision-makers who shape the businesses and economies of the future. This book presents the results of international research, analyses, and experiences with start-ups, delving into their strengths and weaknesses as well as the challenges and attitudes that drive their quest for success. It identifies and analyzes various determinants that shape entrepreneurship, shedding light on new conditions that inspire and affect running a business in a new dynamically changing economic reality. It also presents strategies and concepts used by novice entrepreneurs to overcome market challenges and build thriving enterprises from scratch. Through an analysis of start-ups from various industries and countries, contributions showcase patterns and best practices that determine their growth, and the secrets of their extraordinary achievements are discovered. The power of cooperation between the academic environment and enterprises that jointly create innovations is also highlighted, as well as the impact of the educational systems and cultural norms that support networks on promoting ecology and an environment that encourages and supports entrepreneurial ventures. By analyzing the success of entrepreneurship in various regions and countries, this edited collection reveals the relationships among policy frameworks, access to resources, and the development of dynamic entrepreneurial ecosystems. It will be of interest to researchers, academics, and advanced students in the fields of entrepreneurship, innovation, and economic development.