The book presents a collection of peer-reviewed articles from the International Conference on Innovations in Cyber Physical Systems (ICICPS 2020). The conference provided opportunities for the presentation of new research results and discussion about them. It was also an opportunity to generation of new ideas in all CPS aspects, including theory, tools, applications, systems, test-beds and field deployments. The range of topics explored is wide, and covers security, control, optimization, machine learning, game theory, mechanism design, mobile and cloud computing, model-based design, verification, data mining/analytics, signal processing, and human-in-the-loop shared or supervisory control. This book will be useful to researchers, students, industrialist, developers, and practitioners alike.