Why write a book about science, technology, and medicine in Lisbon? No one questions the value of similar studies of European capital cities such as Paris or London, but they are not reflective of the norm. Alongside its unique characteristics, Lisbon more closely represents the rule and deserves attention as such. This book offers the first urban history of science, technology and medicine in Lisbon, 1840–1940. It addresses the hybrid character of a European port city, scientific capital and imperial metropolis. It discusses the role of science, technology, and medicine in the making of Lisbon, framed by the analysis of invisibilities, urban connections, and techno-scientific imaginaries. The book is accompanied by a virtual interactive map.