This book presents select proceedings of the 4th Structural Integrity Conference and Exhibition (SICE-2022), organized at the Indian Institute of Technology, Hyderabad. This book includes chapters written by eminent scientists and academicians broadly working in aerospace, civil, and mechanical and materials engineering within the areas of structural integrity, life prediction, and condition monitoring. These chapters are classified under the domains of aerospace, fracture mechanics, fatigue, civil structures, experimental techniques, computation mechanics, molecular dynamics and nanostructures, smart materials, energy impact, dynamics, mechanisms, structural optimization, composites, AI/ML applications, additive and advanced manufacturing, bio-engineering, structural health monitoring, nondestructive testing, and damage and failure analysis. The book can be a valuable reference for researchers, students and practicing engineers.