High time-resolution astrophysics (HTRA) involves measuring and studying astronomical phenomena on timescales of seconds to milliseconds. Although many areas of astronomy, such as X-ray astronomy and pulsar observations, have traditionally required high time-resolution studies, HTRA techniques are now being applied to optical, infrared and gamma-ray wavelength regimes, due to the development of high efficiency detectors and larger telescopes that can gather photons at a higher rate. With lectures from eminent scientists aimed at young researchers and postdoctorate students in observational astronomy and astrophysics, this volume gives a practical overview and introduction to the tools and techniques of HTRA. Just as multi-spectral observations of astrophysical phenomena are already yielding new scientific results, many astronomers are optimistic that exploring the time domain will open up an important new frontier in observational astronomy over the next decade.