This report describes interventions for orphans and vulnerable children (OVC) at four sites in South Africa. The project sites are the Rustenburg and Orkney areas in the North West province, and the Kopanong and Matjhabeng municipalities in the Free State. The report highlights the knowledge, attitudes, practices, prevention, care and support issues concerning HIV/AIDS among the people located in these 4 areas.In 2002, the Human Sciences Research Council (HSRC) was commissioned by the WK Kellogg Foundation to develop and implement a five-year intervention project focusing on orphans and vulnerable children (OVC) in southern Africa. In collaboration with several partner organisations, the project currently focuses on how children, families and communities in Botswana, South Africa and Zimbabwe are coping with the impact of HIV/AIDS. The aim of the project is to develop models of best practice so as to enhance and improve support structures for OVC in the southern African region as a whole.