The highly virulent C-virus became a global disaster, but where did the outbreak start? In this prequel to the hit Resident Evil 6 game, the terrifying origins are revealed.

Professor Wright and his nephew Ricky continue their investigation of the biohazard outbreak at the Marhawa school. Upon entering an underground lab where the incident first occurred, they find evidence of the hooded woman, a prime suspect in bioterrorism events worldwide. As the number of victims grows, the hooded woman finally appears. Her identity may now be known, but the situation takes a grim turn for the worse...