Most vertebrate cranial sense organs arise from placodes. These placodes give rise to sensory neurons that transmit information to the brain and neurosecretory cells. This book reviews the evolutionary origin of the sensory and neurosecretory cell types. It summarizes our current understanding of vertebrate evolution, clarifies conceptual issues relating to homology and evolutionary innovation of cell types, compares the sensory and neurosecretory cell types with similar cell types in other animals, and addresses the question of how cranial placodes evolved as novel structures in vertebrates by redeploying pre-existing and sometimes evolutionarily ancient cell types.