In the field of orthopedic surgery, additional areas of application and new indications have been discovered for fibrin glue treatment, for example, hemostasis in pseudotumors in hemophilic patients or in torn ligaments, and in spongiosa transplantation, primarily when nonautologous bone material is being used, or to fill large defects. In maxillofacial surgery fibrin glue is mainly used for osseous contouring of the facial and frontal bones, for alveolar ridge augmentations in preprosthetic surgery, and for soft tissue reconstructions.