The stroke is the third leading cause of death and disability across the globe. We have evolved from a sense of frustration and helplessness to proactive and effective management in the hyperacute and acute phase of a stroke. The aim is to salvage the ischemic brain and turn it again into a viable and functional one. Advances in imaging and newer therapeutic strategies of this devastating illness have changed our outlook. The modern management of an ischemic stroke involves intravenous thrombolysis within a window period of four and half hours. Endovascular management with newer stent retrievers has a higher rate of recanalization with an extended therapeutic window. A new era has emerged in the management of ischemic stroke treatment. This book, written by experts, aims to improve the understanding of stroke medicine for postgraduate medical students in medicine and neurology who have an interest in stroke care.