Light-Cone 2015 belongs to a conference series that started in 1991 under the supervision of the International Light Cone Advisory Committee and showed, year by year, to play a vital role in promoting the research towards a rigorous description of hadrons and nuclei, based on Light-Cone quantization methods. A strong relation with the experimental activity represents an important commitment of the Light-Cone community, with the ambition ''to assist in the development of crucial experimental tests at hadron facilities''. This work is comprised of selected papers presented by researchers at new facilities, such as the 12 GeV upgrade of Th. Jefferson Natl. Lab, the FAIR facility at GSI, J-PARC, and other facilities around the globe, at the Light-Cone meeting in Frascati, Italy in 2015.