This book discusses the Versatile Video Coding (VVC), the ISO and ITU state-of-the-art video coding standard. VVC reaches a compression efficiency significantly higher than its predecessor standard (HEVC) and it has a high versatility for efficient use in a broad range of applications and different types of video content, including Ultra-High Definition (UHD), High-Dynamic Range (HDR), screen content, 360º videos, and resolution adaptivity. The authors introduce the novel VVC tools for block partitioning, intra-frame and inter-frames predictions, transforms, quantization, entropy coding, and in-loop filtering. The authors also present some solutions exploring VVC encoding behavior at different levels to accelerate the intra-frame prediction, applying statistical-based heuristics and machine learning (ML) techniques.