The book provides conceptual and empirical insights into the complex relationship between knowledge flows and regional growth in the EU. The author critically scrutinizes and enhances the RIS (Regional Innovation System) approach, discussing innovation as a technological, institutional and evolutionary process. Moreover, she advances the ongoing discourse on the role of space and technological proximity in the process of innovation and technological externalities. The book closes with an investigation of the role of technological change and knowledge spillovers in the dynamic growth and “catching-up” of EU regions. ​