This issue of Clinics in Podiatic Medicine and Surgery is the second of two dealing with Total Ankle Replacement, guest edited by Dr. Thomas Roukis. Article topics include: Modes of failure of current total ankle replacement systems, Peri-prosthetic aseptic osteolysis: cause and management, Revision of the infected total ankle replacement, Fusion following failed total ankle replacement, Tibiotalocalcaneal arthrodesis with retrograde intramedullary compression nail fixation for salvage of failed total ankle replacement: A systematic review, Management of the failed AgilityT ankle replacement, Management of the failed INBONET ankle replacement, and Outcomes following cyst curettage and bone grafting for the management of peri-prosthetic cystic changes after AEST Total Ankle Replacement.