This volume in The Year in Immunology series focuses on reviewscovering novel approaches to our understanding of immunoregulatorymechanisms. A wide-range of topics is covered within thisvolume, including: Lineage determination of T cells Roles of various receptors in B-cell activation Activation of plasmactyoid dendritic cells Micro-RNAs (miRNAs) in inflammation and immunity Autoimmune disorders NOTE: Annals volumes are available for sale as individual booksor as a journal. For information on institutional journalsubscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciencesdirectly to place your order (www.nyas.org). Members of the NewYork Academy of Science receive full-text access to the Annalsonline and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspxfor more information about becoming a member.