The Gamma-Ray Astrophysics 2001 Symposium offered the opportunity for participants to discuss important results from the nine years of operations of the Compton Gamma-Ray Observatory (CGRO), which ceased operations on June 4, 2000. Discussions also included new results from current missions such as HETE-II, Chandra, and XMM-Newton. In addition, results from ground-based VHE gamma-ray and radion observatories, and other ground-based and space missions related to high energy astrophysical sources were discussed. On the horizon, new gamma-ray space telescopies like GLAST, Swift, INTEGRAL, and AGILE will be launched in the next few years. Papers include mission capabilities and anticipated science from these upcoming missions.