While Fuller’s turn in this direction has invited at least as much criticism as his earlier work, to him the result is an extended sense of the knower, or ‘humanity 2.0’, which Fuller himself identifies with transhumanism. The authors assess Fuller’s work on the following issues: Science and Technology Studies (STS), the university and intellectual life, neo-liberal political economy, intelligent design, Cosmism, Gnosticism, agent-oriented epistemology, proactionary vs precautionary principles and Welfare State 2.0.