The book constitutes the refereed proceedings of the 6th International Conference on Distributed Computing in Sensor Systems, DCOSS 2010, held in Santa Barbara, CA, USA, in June 2010. The 28 revised full papers presented were carefully reviewed and selected from 76 submissions. The research contributions in this proceedings span important aspects of sensor systems, including energy management; communication; coverage and tracking; time synchronization and scheduling; key establishment and authentication; compression; medium access control; code update; and mobility.