In an increasingly interconnected and interdependent world, regional cooperation has immense potential. Countries are collaborating more to address challenges that cannot be addressed individually and also to promote regional public goods. The United Nations Development Programme (UNDP), structured along regional lines with five regional bureaux, has supported regional cooperation through its regional programmes and engagement with regional bodies. The entirety of UNDP work and presence at the regional level has not been evaluated to date. As countries are seeking quicker support and concrete results, and nurturing new forms of partnership in development, UNDP’s significant investment at the regional level needs to be justified and built on lessons learned. Assessing the regional dimension of UNDP work and contribution is thus timely and critical.