With genetic engineering, systems explored in this book now exist allowing
for the simple, efficient, and near universally precise genetic manipulation
directly in any organism, including the mouse. Herein, these models are applied
to a wide field of disease areas, including diabetes, cardiovascular disease,
skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinal
disorders, as well as various behavioral models. Written for the highly
successful Methods in Molecular Biology
series, chapters include introductions to their respective topics, lists of the
necessary materials and reagents, step-by-step, readily reproducible laboratory
protocols, and tips on troubleshooting and avoiding known pitfalls. 
Practical
and fully updated, Mouse Models for Drug
Discovery: Methods and Protocols, Second Edition serves to equip the reader with an extensive overview
of techniques to utilize the many possibilities of mice in the drug development
process.