Infectious diseases once thought to be controlled (such as malaria and tuberculosis) are now spreading rapidly across the globe, and lethal new disease agents (HIV/AIDS, ebola and BSE) continue to emerge at an ominous pace. Policymakers must consider the implications of disease proliferation for economic prosperity, general well-being, and national security in affected societies. This work represents a collection of articles from the premier authors in the field on the ramifications of disease emergence for international development, international law, and national security.