This issue of Radiologic Clinics of North America focuses on Imaging of Selected Multi-System Disorders. Articles will include: von Hippel-Lindau syndrome: Review of Genetics and Imaging; Cross-sectional Imaging Review of Tuberous Sclerosis; Multiple Endocrine Neoplasia Syndromes: A Comprehensive Imaging Review; Imaging Manifestations of Thoracic Tuberculosis; Imaging Spectrum of Extra-Thoracic Tuberculosis; MDCT and MRI Findings of Mycotic Infections; Imaging of Sarcoidosis: A Contemporary Review; Imaging of Inflammatory Myofibroblastic Tumor; Recent Advances in Imaging of IgG4-related Disease; Systemic Vasculopathy Syndromes: Overview of Imaging & Management; Taxonomy and Imaging Manifestations of Systemic Amyloidosis; State of the Art Imaging & Staging of Multiple Myeloma & Plasmacytoma; Solitary Fibrous Tumor: 2016 Imaging Update; and more!