Enemies of Civilization is a work of comparative history and cultural consciousness that discusses how "others" were perceived in three ancient civilizations: Mesopotamia, Egypt, and China. Each civilization was the dominant culture in its part of the world, and each developed a mind-set that regarded itself as culturally superior to its neighbors. Mu-chou Poo compares these societies' attitudes toward other cultures and finds differences and similarities that reveal the self-perceptions of each society.

Notably, this work shows that in contrast to modern racism based on biophysical features, such prejudice did not exist in these ancient societies. It was culture rather than biophysical nature that was the most important criterion for distinguishing us from them. By examining how societies conceive their prejudices, this book breaks new ground in the study of ancient history and opens new ways to look at human society, both ancient and modern.