This conference aims to bring biologists, medical and health-science researchers together with computational scientists to focus on problems at the frontier of computational life sciences. The conference proceedings consists of research papers addressing novel applications of computer, physical, engineering and mathematical models for solving modern challenging problems in life sciences. Topics include image analysis, computer vision, pattern analysis and classification, information visualization, signal processing, control theory, information theory, statistical analysis, numerical analysis, fractals and chaos, optimization, simulation and modeling, computational intelligence methods, machine learning, data mining, decision support systems, database integration and management.