This book provides reviews of the epidemiology, evaluation, and patient management of central nervous system (CNS) injuries. Internationally recognized clinicians and basic scientists discuss recent research that has significantly advanced the understanding of the pathophysiology of neuronal death and facilitated development of new therapeutic approaches.
Novel therapeutic agents evaluated in animal models and currently in clinical trials include:
calcium antagonists
glutamate receptor antagonists
inhibitors of glutamate release
endothelial adhesion and nerve growth factors
opioids
antioxidants, gangliosides
thrombolytic agents
All of these options, as well as hypothermia as a potentially therapeutic approach, are discussed in this comprehensive volume. It will be invaluable to neurologists, neurosurgeons, intensivists, and emergency medicine physicians who care for CNS injured patients.

Contributions by: Karl A. Rudolphi, Tracy K. McIntosh, Edward D. Hall, Anne Marie Dixon, Ronald L. Hayes, Pak H. Chan, Anne M. Guyot, Anthony J. Orencia