Contemporary transatlantic relations have been plagued by a seemingly endless series of disputes over trade and other economic and political interests. Some of these disputes have been amongst the most prominent of the WTO era: the Bananas Case, the Beef Hormones Case and the application of the Helms-Burton Act. This book analyses the source of transatlantic disputes, the means employed to prevent and settle such disputes both bilaterally and through the dispute settlement mechanism of the of the WTO, and promising areas for reform. The book begins with a survey of transatlantic governance and dispute settlement problems. Part II analyses 14 case studies of transatlantic economic and regulatory disputes written by leading EU and US experts. The analytical papers in Part III examine the disputes in the broader context of legal, economic and political theories of dispute prevention and dispute settlement, and part IV offers policy recommendations from EU and US policy-makers and academics.