This book constitutes the refereed proceedings of the 28th Argentine Congress on Computer Science, CACIC 2022, held in La Rioja, Argentina, during October 3–6, 2022. The 20 full papers included in this book were carefully reviewed and selected from 184 submissions. They were organized in topical sections as follows: Agents and Systems; Technology Applied to Education; Graphic Computation, Images and Visualization; Software Engineering; Databases and Data Mining; Hardware Architectures, Networks, and Operating Systems; Innovation in Software Systems; Signal Processing and Real-Time Systems; Innovation in Computer Science Education; and Digital Goverance and Smart Cities.